Basic Information
VIS ID
TVIS10000074
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1739
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG| |AGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh38.p7
Start
199824110 (Hg38)
End
199824110 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-101-1/Upstream/964957; hsa-mir-1182/Downstream/1895398;
Nearest TSS
ENST00000473358/Upstream/675512; ENST00000447034/Downstream/203492;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1664876, chr1-CpG: 36/Downstream/211236
Nearby gene
RNU6-778P(+64049) ;
Downstream sequence
GGCATTGCCACTGTTATATTACTATCCTAT
Junction sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGGGCATTGCCACTGTTATATTACTATCCTAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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