Basic Information
VIS ID
TVIS10000079
Fusion event
HBV-MTRNR2L11 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1820
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh38.p7
Start
237943903 (Hg38)
End
237943903 (Hg38)
Orient
-
Location type
Intronic
Target gene
MTRNR2L11
miRNAs that regulate target gene
hsa-mir-4677-5p ; hsa-mir-1229-5p ; hsa-mir-1225-5p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-26b-3p ; hsa-mir-1266-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-5100 ; hsa-mir-3117-3p ; hsa-mir-4680-5p ; hsa-mir-4539 ; hsa-mir-4330 ; hsa-mir-1288-5p ; hsa-mir-8083 ; hsa-mir-3169 ; hsa-mir-4759 ; hsa-mir-3646 ; hsa-mir-6802-3p ; hsa-mir-6793-3p ; hsa-mir-6879-3p ; hsa-mir-370-5p ; hsa-mir-3661 ; hsa-mir-3663-5p ; hsa-mir-3664-5p ; hsa-mir-378j ; hsa-mir-4527 ; hsa-mir-4714-5p ; hsa-mir-4738-3p ; hsa-mir-514a-5p ; hsa-mir-619-3p ; hsa-mir-631 ; hsa-mir-6503-5p ; hsa-mir-6753-3p ; hsa-mir-6764-3p ; hsa-mir-6824-3p ; hsa-mir-6839-5p ; hsa-mir-7107-3p ; hsa-mir-7152-3p
Nearest miRNA
hsa-mir-101-1/Upstream/472712; hsa-mir-3123/Downstream/3188369;
Nearest TSS
ENST00000473358/Upstream/52981; ENST00000422844/Downstream/1372;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/159755, chr1-CpG: 91/Downstream/1443052
Downstream sequence
ATAAATTGGTCTGCGCACCAGCACCATGCA
Junction sequence
ACGTGATCTGAGTTCAGACCGGAGTAATCCATAAATTGGTCTGCGCACCAGCACCATGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate