Basic Information
VIS ID
TVIS10000080
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1801
Integrated sequence
GGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTC| |TGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGG
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh38.p7
Start
244735225 (Hg38)
End
244735225 (Hg38)
Orient
-
Fragile sites / regions
FRA1I
Nearest miRNA
hsa-mir-101-1/Upstream/1388970; hsa-mir-3124/Downstream/2466742;
Nearest TSS
ENST00000473358/Upstream/4201; ENST00000366528/Downstream/100097;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4161, chr1-CpG: 118/Downstream/99496
Nearby gene
DESI2(-26192) ; COX20(+100097) ;
Downstream sequence
TACTAGGAGGCTGTAGGCATAAATTGGTC
Junction sequence
GCTCACACCCACCAATCTTAACACAACTTATACTAGGAGGCTGTAGGCATAAATTGGTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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