Basic Information
VIS ID
TVIS10000082
Fusion event
HBV-TRAPPC12 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1828
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh38.p7
Start
3447571 (Hg38)
End
3447571 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRAPPC12
miRNAs that regulate target gene
hsa-mir-1914-5p ; hsa-mir-744-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10b/Downstream/2527091;
Nearest TSS
ENST00000437798/Upstream/3703; ENST00000479955/Downstream/1625;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/58842, chr2-CpG: 30/Downstream/1004
Downstream sequence
GTCTGCGCACCAGCACCATGCAACTTTTTC
Junction sequence
GCTTGGTACCGTCCCTATGGCAATGAATGAGTCTGCGCACCAGCACCATGCAACTTTTTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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