Basic Information
VIS ID
TVIS10000085
Fusion event
HBV-LOC105374754 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1740
Integrated sequence
TGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGA| |GTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAA
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh38.p7
Start
59321202 (Hg38)
End
59321202 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105374754
Nearest miRNA
hsa-mir-1301/Upstream/3320407; hsa-mir-10b/Downstream/1066160;
Nearest TSS
ENST00000437798/Upstream/71530; ENST00000415159/Downstream/66957;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/892225, chr2-CpG: 103/Downstream/1139485
Downstream sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGA
Junction sequence
AAATATTTAACTCTGTGTTTGTGTCAATGACAAAGACTGTTTGTTTAAAGACTGGGAGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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