Basic Information
VIS ID
TVIS10000088
Fusion event
HBV-chr2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1811
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh38.p7
Start
77728773 (Hg38)
End
77728773 (Hg38)
Orient
-
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/2637859; hsa-mir-10b/Downstream/1920521;
Nearest TSS
ENST00000437798/Upstream/56558; ENST00000443419/Downstream/187161;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2017760, chr2-CpG: 32/Downstream/1264293
Downstream sequence
GCTGTAGGCATAAATTGGTCTGCGCACCAG
Junction sequence
GTTGTGTTTCTTCACTTTCAGTGCCATTTGGCTGTAGGCATAAATTGGTCTGCGCACCAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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