Basic Information
VIS ID
TVIS10000090
Fusion event
HBV-LOC101928214 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1824
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh38.p7
Start
87657492 (Hg38)
End
87657492 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
LOC101928214
Nearest miRNA
hsa-mir-1285-2/Upstream/27658; hsa-mir-10b/Downstream/425027;
Nearest TSS
ENST00000437798/Upstream/53402; ENST00000359481/Downstream/90595;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/314998, chr2-CpG: 29/Downstream/168174
Nearby gene
MIR4435-1(-27658) ; PLGLB2(+90595) ;
Downstream sequence
ACTTGAAGATGCTGCACACATCCTGTGTGG
Junction sequence
ATTGGTCTGCGCACCAGCACCATGCAACTTACTTGAAGATGCTGCACACATCCTGTGTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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