Basic Information
VIS ID
TVIS10000091
Fusion event
HBV-LOC105373501 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1825
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh38.p7
Start
98046798 (Hg38)
End
98046798 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
LOC105373501
Nearest miRNA
hsa-mir-1285-2/Upstream/1248445; hsa-mir-10b/Downstream/3262652;
Nearest TSS
ENST00000437798/Upstream/50907; ENST00000484571/Downstream/40318;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/50317, chr2-CpG: 61/Downstream/40093
Nearby gene
TMEM131(-50907) ; VWA3B(+40318) ;
Downstream sequence
TTGGTCTGCGCACCAGCACCATGCAACTTT
Junction sequence
ATATGTTACAGGACTCCAACACTTACCCAATTGGTCTGCGCACCAGCACCATGCAACTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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