Basic Information
VIS ID
TVIS10000092
Fusion event
HBV-LINC01102 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1757
Integrated sequence
AAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTA| |GATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh38.p7
Start
104453927 (Hg38)
End
104453927 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LINC01102
Nearest miRNA
hsa-mir-1285-2/Upstream/2021561; hsa-mir-10b/Downstream/4687563;
Nearest TSS
ENST00000437798/Upstream/19549; ENST00000438566/Downstream/56582;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1716972, chr2-CpG: 44/Downstream/205203
Downstream sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTA
Junction sequence
AATTTGGCCCTCCTTATCTGTGGGTTCCAAAAGACTGGGAGGAGTTGGGGGAGGAGATTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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