VISDB Viral Integration Site DataBase

VIS ID

TVIS10000093

Fusion event

HBV-FHL2 integration

Validated

Yes

Detection method

invPCR

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

End

1828

Integrated sequence

AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT

Chromosome

chr2

Cytoband

q12.2

Reference genome

Start

End

105401855 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-4768-5p ; hsa-mir-6833-3p ; hsa-mir-5698 ; hsa-mir-493-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-143-5p ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-6499-3p ; hsa-mir-3135b ; hsa-mir-5693 ; hsa-mir-764 ; hsa-mir-552-3p ; hsa-mir-4438 ; hsa-mir-6818-3p ; hsa-mir-548s ; hsa-mir-4684-5p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-339-5p ; hsa-mir-5680 ; hsa-mir-28-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p ; hsa-mir-3662 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4999-3p ; hsa-mir-223-5p ; hsa-mir-34c-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-1912 ; hsa-mir-1295b-5p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-6794-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-1236-3p ; hsa-mir-4639-3p ; hsa-mir-6515-3p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-4775 ; hsa-mir-204-3p ; hsa-mir-3153 ; hsa-mir-4261 ; hsa-mir-4646-5p ; hsa-mir-4668-5p ; hsa-mir-508-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-1273g-3p ; hsa-mir-4252 ; hsa-mir-4282 ; hsa-mir-4793-3p ; hsa-mir-6849-3p

Nearest miRNA

hsa-mir-1285-2/Upstream/2969489; hsa-mir-10b/Downstream/3739635;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/2428, chr2-CpG: 164/Downstream/342720

Nearest cancer related gene

FHL2(OG, No orient, 0)

Downstream sequence

GTCTGCGCACCAGCACCATGCAACTTTTTC

Junction sequence