Basic Information
VIS ID
TVIS10000096
Fusion event
HBV-LOC105373567 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1790
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh38.p7
Start
113321667 (Hg38)
End
113321667 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
LOC105373567
Nearest miRNA
hsa-mir-1285-2/Upstream/1550533; hsa-mir-10b/Downstream/261292;
Nearest TSS
ENST00000437798/Upstream/42717; ENST00000453673/Downstream/84729;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30189, chr2-CpG: 27/Downstream/3249
Nearby gene
PAX8(-42717) ; IGKV1OR2-108(+84729) ;
Downstream sequence
GAGTATAACTGGGCATGTGGCACCCACTAG
Junction sequence
TAAAGGTCTTTGTACTAGGAGGCTGTAGGCGAGTATAACTGGGCATGTGGCACCCACTAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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