Basic Information
VIS ID
TVIS10000101
Fusion event
HBV-chr2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
2268
Integrated sequence
CAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACCGTTATAGAGTATTTGGTGTCTTTC| |GGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCC
Host Sequence
Chromosome
chr2
Cytoband
q24.3
Reference genome
GRCh38.p7
Start
166698376 (Hg38)
End
166698376 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-128-1/Upstream/6290494; hsa-mir-10b/Downstream/1884567;
Nearest TSS
ENST00000437798/Upstream/204050; ENST00000409043/Downstream/190111;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/322175, chr2-CpG: 157/Downstream/594147
Nearby gene
SCN7A(-204129) ; XIRP2(+190111) ;
Downstream sequence
GAAACCGTTATAGAGTATTTGGTGTCTTTC
Junction sequence
CACATTCAAATTAAGTTCTTGTGTACTTTTGAAACCGTTATAGAGTATTTGGTGTCTTTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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