ERBB4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000102
Fusion event
HBV-ERBB4 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1836
Integrated sequence
AGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGC| |CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTA
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh38.p7
Start
211886977 (Hg38)
End
211886977 (Hg38)
Orient
+
Location type
Intronic
Target gene
ERBB4
miRNAs that regulate target gene
hsa-mir-372-3p ; hsa-mir-19a-3p ; hsa-mir-302d-3p ; hsa-mir-146a-5p ; hsa-mir-145-5p ; hsa-mir-221-3p ; hsa-mir-302b-3p ; hsa-mir-193a-3p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-10b/Upstream/4132096; hsa-mir-1244-1/Downstream/539286;
Nearest TSS
ENST00000437798/Upstream/221623; ENST00000434559/Downstream/73785;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1410165, chr2-CpG: 86/Downstream/650479
Nearest cancer related gene
ERBB4(OG, No orient, 0)
Downstream sequence
ACCAGCACCATGCAACTTTTTCCTCTGC
Junction sequence
CTCTGCACCTTCAAACTTAAAAGCAAATGTACCAGCACCATGCAACTTTTTCCTCTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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