FHIT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000112
Fusion event
HBV-FHIT integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1712
Integrated sequence
GAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCA| |AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh38.p7
Start
60224598 (Hg38)
End
60224598 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/4372004; hsa-mir-12124/Downstream/393207;
Nearest TSS
ENST00000440867/Upstream/143758; ENST00000475527/Downstream/1026786;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1174380, chr3-CpG: 48/Downstream/1026334
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Downstream sequence
TGTCAACGACCGACCTTGAGGCATACTTCA
Junction sequence
GAGGCATACTTCATGACGTCAGGTTGCTCCTGTCAACGACCGACCTTGAGGCATACTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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