CASR _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000115
Fusion event
HBV-CASR integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1860
Integrated sequence
TAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCT| |ACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGC
Host Sequence
Chromosome
chr3
Cytoband
q21.1
Reference genome
GRCh38.p7
Start
122236732 (Hg38)
End
122236732 (Hg38)
Orient
-
Location type
Intronic
Target gene
CASR
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-135b-5p ; hsa-mir-146b-5p
Nearest miRNA
hsa-let-7g/Upstream/1187017; hsa-mir-12124/Downstream/925062;
Nearest TSS
ENST00000440867/Upstream/52300; ENST00000638296/Downstream/17216;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/6254, chr3-CpG: 41/Downstream/147272
Downstream sequence
TGGGGCTGACCTGAAGTTAAAAGAATTTGC
Junction sequence
CTCTGCCTAATCATCTCTTGTTCATGTCCTTGGGGCTGACCTGAAGTTAAAAGAATTTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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