Basic Information
VIS ID
TVIS10000117
Fusion event
HBV-chr3 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr3
Cytoband
q22.3
Reference genome
GRCh38.p7
Start
137860209 (Hg38)
End
137860209 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7g/Upstream/3422303; hsa-mir-1224/Downstream/13705667;
Nearest TSS
ENST00000440867/Upstream/68236; ENST00000479660/Downstream/138526;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/88047, chr3-CpG: 17/Downstream/149943
Nearby gene
PRPF31(-63531) ; CLDN18(+138526) ;
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
TCTTCATGCCCCACTTAGCACCATAAGGTGTCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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