Basic Information
VIS ID
TVIS10000124
Fusion event
HBV-ADGRL3 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1789
Integrated sequence
GACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGG| |CATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGG
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh38.p7
Start
61836871 (Hg38)
End
61836871 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/914187; hsa-mir-1243/Downstream/4439953;
Nearest TSS
ENST00000502981/Upstream/249503; ENST00000508078/Downstream/58870;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/633788, chr4-CpG: 60/Downstream/1512258
Downstream sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGG
Junction sequence
GAATAATACAAGAAAAATCGAAATCGAAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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