USO1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000127
Fusion event
HBV-USO1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1827
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
GRCh38.p7
Start
75781475 (Hg38)
End
75781475 (Hg38)
Orient
-
Location type
Intronic
Target gene
USO1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-335-5p ; hsa-let-7b-5p ; hsa-mir-421
Nearest miRNA
hsa-mir-12113/Upstream/9504547; hsa-mir-1243/Downstream/792093;
Nearest TSS
ENST00000502981/Upstream/11352; ENST00000508454/Downstream/23534;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/56202, chr4-CpG: 133/Downstream/158461
Downstream sequence
GGTCTGCGCACCAGCACCATGCAACTTTTT
Junction sequence
TTCAGTGAGTCATTTTACTTCCAGTAGAAAGGTCTGCGCACCAGCACCATGCAACTTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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