Basic Information
VIS ID
TVIS10000130
Fusion event
HBV-CCSER1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh38.p7
Start
90834449 (Hg38)
End
90834449 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
CCSER1
miRNAs that regulate target gene
hsa-mir-544a
Nearest miRNA
hsa-mir-12113/Upstream/3533866; hsa-mir-1243/Downstream/8162938;
Nearest TSS
ENST00000502981/Upstream/18636; ENST00000505511/Downstream/278341;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/705918, chr4-CpG: 22/Downstream/4439
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
TTTCATTCAGGAAGAGGGAGATTGTATTGATCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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