PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000134
Fusion event
HBV-PRPF31 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1823
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh38.p7
Start
141262473 (Hg38)
End
141262473 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4C
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-12113/Upstream/15755166; hsa-mir-1305/Downstream/2080987;
Nearest TSS
ENST00000502981/Upstream/41539; ENST00000608088/Downstream/16316;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/41268, chr4-CpG: 69/Downstream/373762
Downstream sequence
AATTGGTCTGCGCACCAGCACCATGCAACT
Junction sequence
ATATATGGTTTATCCTTGAGGGTAATCCATAATTGGTCTGCGCACCAGCACCATGCAACT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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