Basic Information
VIS ID
TVIS10000137
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1754
Integrated sequence
CATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGA| |TTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA
Host Sequence
Chromosome
chr4
Cytoband
q31.23
Reference genome
GRCh38.p7
Start
150040526 (Hg38)
End
150040526 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-12113/Upstream/2257858; hsa-mir-1305/Downstream/2448801;
Nearest TSS
ENST00000502981/Upstream/84318; ENST00000507694/Downstream/37748;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1594622, chr4-CpG: 161/Downstream/37572
Nearby gene
PRPF31(-81954) ; DCLK2(+37748) ;
Downstream sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGA
Junction sequence
CTATCCATTTTTTAAAAAGACTCAGTCCATTTAAAGACTGGGAGGAGTTGGGGGAGGAGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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