Basic Information
VIS ID
TVIS10000139
Fusion event
HBV-chr5 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1720
Integrated sequence
CGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGT| |TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh38.p7
Start
105620585 (Hg38)
End
105620585 (Hg38)
Orient
-
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/4804020; hsa-mir-103a-1/Downstream/4893244;
Nearest TSS
ENST00000502646/Upstream/227615; ENST00000513676/Downstream/1360284;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2360736, chr5-CpG: 253/Downstream/2048844
Nearby gene
PRPF31(-227615) ; RNA5SP189(+302409) ;
Downstream sequence
ACCGACCTTGAGGCATACTTCAAAGACTGT
Junction sequence
ACTGTCAGAACCTTTAGAAAATATTACATCACCGACCTTGAGGCATACTTCAAAGACTGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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