Basic Information
VIS ID
TVIS10000145
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1820
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh38.p7
Start
35437823 (Hg38)
End
35437823 (Hg38)
Orient
+
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/1197087; hsa-mir-10398/Downstream/32685;
Nearest TSS
ENST00000381078/Upstream/95209; ENST00000229769/Downstream/14538;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/94914, chr6-CpG: 81/Downstream/14414
Nearby gene
PPARD(-9632) ; FANCE(+14538) ;
Downstream sequence
ATAAATTGGTCTGCGCACCAGCACCATGCA
Junction sequence
TGATCCAGGACAGGAGGGTGGCACCTAAATATAAATTGGTCTGCGCACCAGCACCATGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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