Basic Information
VIS ID
TVIS10000146
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1827
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh38.p7
Start
37210886 (Hg38)
End
37210886 (Hg38)
Orient
+
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/588374; hsa-mir-10398/Downstream/344479;
Nearest TSS
ENST00000381078/Upstream/38392; ENST00000373491/Downstream/7603;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/39228, chr6-CpG: 29/Downstream/46696
Nearby gene
PIM1(-35460) ; TMEM217(+1294) ;
Nearest cancer related gene
PIM1(OG, -35460) ;
Downstream sequence
GGTCTGCGCACCAGCACCATGCAACTTTTT
Junction sequence
AGCCGACTTTCGTGTATGAAGTCATATGATGGTCTGCGCACCAGCACCATGCAACTTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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