DAAM2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000147
Fusion event
HBV-DAAM2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1712
Integrated sequence
GAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCA| |AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh38.p7
Start
39821987 (Hg38)
End
39821987 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
DAAM2
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-18a-5p ; hsa-mir-335-5p ; hsa-mir-4707-3p ; hsa-mir-7108-3p ; hsa-mir-589-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-943 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6752-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p
Nearest miRNA
hsa-mir-1236/Upstream/747606; hsa-mir-10398/Downstream/1776736;
Nearest TSS
ENST00000381078/Upstream/28969; ENST00000405961/Downstream/26579;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29337, chr6-CpG: 17/Downstream/79816
Downstream sequence
AGCAACAGCGGACAGTGTCGTAGTGGGAGG
Junction sequence
TGTCAACGACCGACCTTGAGGCATACTTCAAGCAACAGCGGACAGTGTCGTAGTGGGAGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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