EYS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000148
Fusion event
HBV-EYS integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh38.p7
Start
65198779 (Hg38)
End
65198779 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/7808567; hsa-mir-10524/Downstream/6178181;
Nearest TSS
ENST00000381078/Upstream/485444; ENST00000449928/Downstream/104158;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1562219, chr6-CpG: 22/Downstream/102581
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
ATTTGGTTGTTCAGATTAGGTGGTAACCTTTCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate