Basic Information
VIS ID
TVIS10000152
Fusion event
HBV-UBE3D integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1826
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh38.p7
Start
83019975 (Hg38)
End
83019975 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE3D
Nearest miRNA
hsa-mir-10398/Upstream/4480666; hsa-mir-1202/Downstream/7292767;
Nearest TSS
ENST00000381078/Upstream/87374; ENST00000604380/Downstream/37994;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/654373, chr6-CpG: 39/Downstream/45680
Downstream sequence
TGGTCTGCGCACCAGCACCATGCAACTTTT
Junction sequence
CTGCCCGCTTCTCCACAGACTTCCTCTTTATGGTCTGCGCACCAGCACCATGCAACTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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