Basic Information
VIS ID
TVIS10000157
Fusion event
HBV-PRKN integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1765
Integrated sequence
TCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
GRCh38.p7
Start
161834757 (Hg38)
End
161834757 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6E
Target gene
PRKN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3187-3p ; hsa-mir-1303 ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-483-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10398/Upstream/3070004; hsa-mir-1913/Downstream/4674597;
Nearest TSS
ENST00000381078/Upstream/265337; ENST00000544266/Downstream/428011;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/188100, chr6-CpG: 75/Downstream/892587
Nearest cancer related gene
PRKN(TSG, No orient, 0)
Downstream sequence
GAGGAGTTGGGGGAGGAGATTAGATTAAAG
Junction sequence
AGCATCAGCTTTTCTTGCATTCTCTGAAACGAGGAGTTGGGGGAGGAGATTAGATTAAAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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