ZNF727 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000163
Fusion event
HBV-ZNF727 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1828
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh38.p7
Start
64060535 (Hg38)
End
64060535 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
ZNF727
Nearest miRNA
hsa-mir-1183/Upstream/439366; hsa-mir-10399/Downstream/618529;
Nearest TSS
ENST00000635602/Upstream/15092; ENST00000442436/Downstream/79960;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/14615, chr7-CpG: 51/Downstream/39506
Downstream sequence
GTCTGCGCACCAGCACCATGCATTTTTTTC
Junction sequence
TTTCAATGCACTTGGCACCTTCAGACCTGAGTCTGCGCACCAGCACCATGCATTTTTTTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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