AUTS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000164
Fusion event
HBV-AUTS2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1809
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh38.p7
Start
70172146 (Hg38)
End
70172146 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/3057749; hsa-mir-10399/Downstream/1135526;
Nearest TSS
ENST00000635602/Upstream/37590; ENST00000475660/Downstream/144770;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/572095, chr7-CpG: 64/Downstream/423702
Downstream sequence
GAAAGCTGCAAACTTCCTATATGGCCATGG
Junction sequence
AGGCTGTAGGCATAAATTGGTCTGCGCACCGAAAGCTGCAAACTTCCTATATGGCCATGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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