Basic Information
VIS ID
TVIS10000166
Fusion event
HBV-chr7 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1827
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh38.p7
Start
104937325 (Hg38)
End
104937325 (Hg38)
Orient
-
Fragile sites / regions
FRA7F
Nearest miRNA
hsa-mir-10525/Upstream/2465794; hsa-mir-10399/Downstream/9716020;
Nearest TSS
ENST00000635602/Upstream/608625; ENST00000415513/Downstream/3738;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/607814, chr7-CpG: 45/Downstream/46565
Nearby gene
LHFPL3-AS2(-10680) ; PRPF31(+3738) ;
Downstream sequence
GTCTGCGCACCAGCACCATGCAACTTCTTT
Junction sequence
TTTAATATTCTTTTTTCATACTAAGTCCTTGTCTGCGCACCAGCACCATGCAACTTCTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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