Basic Information
VIS ID
TVIS10000167
Fusion event
HBV-CTB-30L5.1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1807
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh38.p7
Start
106758712 (Hg38)
End
106758712 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
CTB-30L5.1
Nearest miRNA
hsa-mir-10525/Upstream/4287181; hsa-mir-10399/Downstream/7894633;
Nearest TSS
ENST00000635602/Upstream/97716; ENST00000470135/Downstream/16299;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/97585, chr7-CpG: 58/Downstream/108900
Downstream sequence
GGAGGCTGTAGGCATAAATTGGTCTGCGCA
Junction sequence
CAGACTGAATTTGAGCAGAGATGTAAAGAAGGAGGCTGTAGGCATAAATTGGTCTGCGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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