ANGPT2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000171
Fusion event
HBV-ANGPT2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1819
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh38.p7
Start
6544918 (Hg38)
End
6544918 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANGPT2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-542-3p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-3674/Upstream/4468278; hsa-mir-10400/Downstream/77206;
Nearest TSS
ENST00000518652/Upstream/67559; ENST00000521175/Downstream/18126;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/138117, chr8-CpG: 53/Downstream/21776
Downstream sequence
CATAAATTGGTCTGCGCACCAGCACCATGC
Junction sequence
TTTTGTTCTCACAATGGAATTATTATTTTGCATAAATTGGTCTGCGCACCAGCACCATGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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