Basic Information
VIS ID
TVIS10000172
Fusion event
HBV-FAM85B integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1828
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh38.p7
Start
8187895 (Hg38)
End
8187895 (Hg38)
Orient
-
Location type
Intronic
Target gene
FAM85B
Nearest miRNA
hsa-mir-3674/Upstream/98806; hsa-mir-10400/Downstream/860550;
Nearest TSS
ENST00000518652/Upstream/209910; ENST00000524073/Downstream/1300;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/121817, chr8-CpG: 118/Downstream/39599
Downstream sequence
GTCTGCGCACCAGCACCATGCAACTTTTTC
Junction sequence
ATGCAACTTTTTCTTTTCCTCTTTCTCAAGTCTGCGCACCAGCACCATGCAACTTTTTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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