TUSC3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000173
Fusion event
HBV-TUSC3 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1810
Integrated sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCA| |GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh38.p7
Start
15600719 (Hg38)
End
15600719 (Hg38)
Orient
-
Location type
Intronic
Target gene
TUSC3
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-1229-3p ; hsa-mir-25-3p ; hsa-mir-181a-5p ; hsa-mir-30e-5p
Nearest miRNA
hsa-mir-124-1/Upstream/747209; hsa-mir-10400/Downstream/2080859;
Nearest TSS
ENST00000518652/Upstream/39100; ENST00000509177/Downstream/22359;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/59941, chr8-CpG: 46/Downstream/1400816
Downstream sequence
GGCTGTAGGCATAAATTGGTCTGCGCACCA
Junction sequence
AAAGTGATTTTAATTCTTAACTTACATGGCGGCTGTAGGCATAAATTGGTCTGCGCACCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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