Basic Information
VIS ID
TVIS10000176
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1692
Integrated sequence
TCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGAC| |CGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCAT
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh38.p7
Start
76394528 (Hg38)
End
76394528 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-124-1/Upstream/1688781; hsa-mir-10400/Downstream/572240;
Nearest TSS
ENST00000518652/Upstream/854659; ENST00000603284/Downstream/9470;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/986339, chr8-CpG: 59/Downstream/287492
Nearby gene
RNU2-54P(-128796) ; PRPF31(+9470) ;
Downstream sequence
GACTCTTGGACTCTCTGCAATGTCAACGAC
Junction sequence
TGGTGGGTGGGTTTTGCCCTCAGTTTGAAGGACTCTTGGACTCTCTGCAATGTCAACGAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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