PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000177
Fusion event
HBV-PRPF31 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1793
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh38.p7
Start
80278777 (Hg38)
End
80278777 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-12123/Upstream/37304; hsa-mir-10400/Downstream/10926708;
Nearest TSS
ENST00000518652/Upstream/12623; ENST00000379091/Downstream/206842;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/12821, chr8-CpG: 188/Downstream/207065
Downstream sequence
AGGTCTTTGTACTAGGAGGCTGTAGGCATA
Junction sequence
GAGGCTGTAGGCATAGCAGGATCTTGTTTAAGGTCTTTGTACTAGGAGGCTGTAGGCATA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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