ABRA _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000178
Fusion event
HBV-ABRA integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1827
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh38.p7
Start
106793794 (Hg38)
End
106793794 (Hg38)
Orient
+
Location type
Intronic
Target gene
ABRA
miRNAs that regulate target gene
hsa-mir-628-5p
Nearest miRNA
hsa-mir-12123/Upstream/2309329; hsa-mir-10400/Downstream/5849699;
Nearest TSS
ENST00000518652/Upstream/23549; ENST00000520037/Downstream/501747;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/135431, chr8-CpG: 92/Downstream/1288833
Nearby gene
ABRA(-23549) ; ANGPT1(+455688) ;
Downstream sequence
GGTCTGCGCACCAGCACCATGCAACTTTTT
Junction sequence
ACGGTAAACGCACCAGTCAGCACTCTGTAAGGTCTGCGCACCAGCACCATGCAACTTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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