Basic Information
VIS ID
TVIS10000179
Fusion event
HBV-LOC107986970 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1828
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr8
Cytoband
q24.11
Reference genome
GRCh38.p7
Start
117740571 (Hg38)
End
117740571 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
LOC107986970
Nearest miRNA
hsa-mir-12123/Upstream/865771; hsa-mir-10400/Downstream/1584600;
Nearest TSS
ENST00000518652/Upstream/210207; ENST00000366457/Downstream/369843;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/219499, chr8-CpG: 76/Downstream/371164
Nearby gene
MED30(-200309) ; EXT1(+53919) ;
Downstream sequence
GTCTGCGCACCAGCACCATGCAACTTTTTC
Junction sequence
TTTTTCGACTGGATTAAGAAAATGTGGCACGTCTGCGCACCAGCACCATGCAACTTTTTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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