Basic Information
VIS ID
TVIS10000186
Fusion event
HBV-chr9 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1824
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh38.p7
Start
86907759 (Hg38)
End
86907759 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-101-2/Upstream/2937902; hsa-let-7a-1/Downstream/1838077;
Nearest TSS
ENST00000422679/Upstream/275612; ENST00000415801/Downstream/39430;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/552770, chr9-CpG: 205/Downstream/37910
Nearby gene
PRPF31(-211263) ; GAS1(+36604) ;
Nearest cancer related gene
GAS1(TSG, +36604) ;
Downstream sequence
ATTGGTCTGCGCACCAGCACCATGCAACTT
Junction sequence
GTTTGAGAAATCCTAATCCTGCAGCTCTCAATTGGTCTGCGCACCAGCACCATGCAACTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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