Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000188
Fusion event
HBV-WNK2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
End
1832
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT| |CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
Start
End
93203918 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-222-5p ; hsa-mir-4654 ; hsa-mir-4769-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-5196-5p ; hsa-mir-4493 ; hsa-mir-4747-5p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-760 ; hsa-mir-3160-5p ; hsa-mir-3194-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4267
Nearest miRNA
hsa-mir-101-2/Upstream/675860; hsa-let-7a-1/Downstream/390923;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/18365, chr9-CpG: 20/Downstream/43644
Nearest cancer related gene
WNK2(TSG, No orient, 0)
Downstream sequence
GCGCACCAGCACCATGCAACTTTTTCCCT
Junction sequence
CCTGGCTGGCCCCAACTGCACCATGTCCACGCGCACCAGCACCATGCAACTTTTTCCCT
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).