Basic Information
VIS ID
TVIS10000195
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1821
Integrated sequence
TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh38.p7
Start
44691461 (Hg38)
End
44691461 (Hg38)
Orient
-
Fragile sites / regions
FRA10G
Nearest miRNA
hsa-mir-1265/Upstream/1693780; hsa-mir-107/Downstream/472553;
Nearest TSS
ENST00000439456/Upstream/89357; ENST00000460364/Downstream/219739;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/304518, chr10-CpG: 34/Downstream/173265
Nearby gene
PRPF31(-89357) ; TMEM72-AS1(+119563) ;
Downstream sequence
TAAATTGGTCTGCGCACCAGCACCATGCAA
Junction sequence
AGTTACAAGCCATCAAGGGAAATTTAGTAATAAATTGGTCTGCGCACCAGCACCATGCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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