ANXA8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000196
Fusion event
HBV-ANXA8 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr10
Cytoband
q11.22
Reference genome
GRCh38.p7
Start
47887933 (Hg38)
End
47887933 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
ANXA8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/2723845; hsa-mir-107/Downstream/1097579;
Nearest TSS
ENST00000439456/Upstream/124341; ENST00000576178/Downstream/30806;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/124184, chr10-CpG: 47/Downstream/252161
Nearby gene
SYT15(-124341) ; ANXA8(+20131) ;
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
ACCATGCAACTTTTTCAAAAGAAAAAGATCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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