Basic Information
VIS ID
TVIS10000197
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1825
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh38.p7
Start
55788949 (Hg38)
End
55788949 (Hg38)
Orient
+
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/1180992; hsa-mir-107/Downstream/1515530;
Nearest TSS
ENST00000439456/Upstream/161007; ENST00000489785/Downstream/570782;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/157494, chr10-CpG: 28/Downstream/572349
Nearby gene
PCDH15(-161007) ; ZWINT(+568279) ;
Downstream sequence
TTGGTCTGCGCACCAGCACCATGCAACTTT
Junction sequence
TTTGAAATTTGAAATTAAAAATCAATTAGCTTGGTCTGCGCACCAGCACCATGCAACTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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