Basic Information
VIS ID
TVIS10000198
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1906
Integrated sequence
ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG| |ACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTC
Host Sequence
Chromosome
chr10
Cytoband
q26.12
Reference genome
GRCh38.p7
Start
121374033 (Hg38)
End
121374033 (Hg38)
Orient
-
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1415441; hsa-mir-202/Downstream/1042932;
Nearest TSS
ENST00000439456/Upstream/195333; ENST00000447943/Downstream/106452;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/394155, chr10-CpG: 185/Downstream/223069
Nearby gene
LINC01153(-188067) ; RN7SKP167(+36883) ;
Downstream sequence
AGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Junction sequence
CATGGTAAAATACTAAAGTTCCAGTCAACAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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