PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000200
Fusion event
HBV-PRPF31 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1706
Integrated sequence
CGCATGGAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCAT| |ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh38.p7
Start
132184576 (Hg38)
End
132184576 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-107/Upstream/1221908; hsa-mir-202/Downstream/1062935;
Nearest TSS
ENST00000439456/Upstream/40860; ENST00000493927/Downstream/423;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/43801, chr10-CpG: 264/Downstream/832
Downstream sequence
CTGCAATGTCAACGACCGACCTTGAGGCAT
Junction sequence
GGCATGCCAGGTAGTGTGTGTATTCTCCCACTGCAATGTCAACGACCGACCTTGAGGCAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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