CARS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000201
Fusion event
HBV-CARS integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1818
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh38.p7
Start
3025329 (Hg38)
End
3025329 (Hg38)
Orient
-
Location type
Intronic
Target gene
CARS
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-652-3p ; hsa-mir-92a-3p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-210/Upstream/852191; hsa-let-7a-2/Downstream/830733;
Nearest TSS
ENST00000527297/Upstream/15796; ENST00000630527/Downstream/3680;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/32378, chr11-CpG: 77/Downstream/31583
Downstream sequence
GCATAAATTGGTCTGCGCACCAGTACCTTG
Junction sequence
CTTGAACCTAGGAGGCAGAGGTTATGTTGAGCATAAATTGGTCTGCGCACCAGTACCTTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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