Basic Information
VIS ID
TVIS10000205
Fusion event
HBV-OR5BR1P integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1813
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA| |CCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGA
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh38.p7
Start
59332803 (Hg38)
End
59332803 (Hg38)
Orient
-
Location type
Intronic
Target gene
OR5BR1P
Nearest miRNA
hsa-mir-129-2/Upstream/1691517; hsa-let-7a-2/Downstream/262274;
Nearest TSS
ENST00000527297/Upstream/48770; ENST00000313940/Downstream/26092;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/159224, chr11-CpG: 34/Downstream/227861
Nearby gene
RN7SL435P(-41470) ; OR5AN1(+31609) ;
Downstream sequence
GATCTACTAACTTGGTCTGCGCACCATCA
Junction sequence
ATCAAAGAGCCCTTTTAGATGGACGAAGTGATCTACTAACTTGGTCTGCGCACCATCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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