Basic Information
VIS ID
TVIS10000206
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1800
Integrated sequence
AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT| |CTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGG
Host Sequence
Chromosome
chr11
Cytoband
q12.2
Reference genome
GRCh38.p7
Start
61659880 (Hg38)
End
61659880 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-129-2/Upstream/151223; hsa-let-7a-2/Downstream/132615;
Nearest TSS
ENST00000527297/Upstream/4178; ENST00000540717/Downstream/20553;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/71989, chr11-CpG: 94/Downstream/20247
Nearby gene
PRPF31(-4178) ; DAGLA(+20553) ;
Downstream sequence
TGTACTAGGAGGCTGTAGGCATAAATTGGT
Junction sequence
AATGCCTAACCATCTGGGAATGCAGCCCAGTGTACTAGGAGGCTGTAGGCATAAATTGGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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