DLG2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000209
Fusion event
HBV-DLG2 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1864
Integrated sequence
GGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTG| |TTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTC
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh38.p7
Start
84573276 (Hg38)
End
84573276 (Hg38)
Orient
-
Location type
Intronic
Target gene
DLG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10392/Upstream/2682440; hsa-let-7a-2/Downstream/1705057;
Nearest TSS
ENST00000527297/Upstream/135467; ENST00000534275/Downstream/147550;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1286783, chr11-CpG: 24/Downstream/1055023
Downstream sequence
GCCTAACCATAACTTGTTAACGTTTTACTG
Junction sequence
TAACCATAACTTGTTAACGTTTTACTGACAGCCTAACCATAACTTGTTAACGTTTTACTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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